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From surface chemistry to nuclear targeting: The multifaceted challenge of genetic delivery via inorganic nanoparticles - ScienceDirect

They cannot be extrapolated to therapeutic recommendations for humans, as species-specific factors, delivery methods, tissue penetration characteristics, and safety profiles have not been established through controlled clinical research

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2 S-nitrosylation: a stable alternative for NO• signaling regulation under inflammatory and oxidative stress NO• is a gaseous free radical synthesized endogenously by three distinct nitric oxide synthase (NOS) isoforms: neuronal NOS (nNOS or NOS1), endothelial NOS (eNOS or NOS3), and inducible NOS (iNOS or NOS2) (9) ( Figure 1A )