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5 Conclusion and future prospects Based on a critical reading and a systemic analysis of recent studies as to the effects of traditional medicine on intestinal barrier function in literature, numerous decoctions and natural compounds have shown a role in animal models of UC by improving the intestinal barrier function via various mechanisms, mainly including regulating the expression of barrier protecting proteins such as the tight junction proteins and mucins, suppressing inflammatory cell infiltration and associated pro-inflammatory mediators, inhibiting oxidative stress, and modulating the composition of gut microbiota and their metabolites