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In animal experiments, STAT6 inhibition reduced the expression of claudin-2, protected the structure and function of the intestinal barrier, and alleviated the symptoms of UC
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The C max values of each dose were 1.05 ± 0.429, 3.30 ± 0.508, and 26.1 ± 7.82 ng/ml, respectively, and the AUC 0–t values were 29.0 ± 2.68, 160 ± 21.0, and 830 ± 247 ng min/mL respectively
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