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In the LPS-induced acutelung injury mouse model, treatment of GHK-Cu also significantly suppressed TNF-α and IL-6 expression with a significant decrease of both NF-κB p65 and p38 MAPK signaling, suggesting that GHK-Cu is useful for the development of novel anti-inflammatory therapies [22]
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Even with all of that, absolute bioavailability remains around 1% or less — which is why the oral dose is many times larger than the equivalent injectable dose
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