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This is very difficult to test directly in practice because it requires direct comparison of the extent of tolerance produced by morphine with opioids that exhibit comparable intrinsic efficacy for G protein activation but much higher efficacy for endocytosis than morphine, while ensuring equivalent receptor stimulation and duration of action

laboratory research only

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These additives, not covalently bound to the polymer matrix, can leach into the soil during film degradation, potentially posing risks to ecosystems and human health