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Capsaicin effects are ascribable to the activation of transient receptor potential channel vanilloid type-1 (TRPV1) [165], causing an influx of Ca 2+ , and subsequent release of neurotransmitters, such as substance P and catecholamines, and other substances like GLP-1 [166]

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It has been speculated that the continued use of bethanechol may result from its use in patients who find the option of undergoing urinary catheterisation intimidating & choose to exhaust less invasive treatment options first, or in select patients where it seems to provide a marginal benefit (Gaitonde et al, 2019)