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Leveraging the available RAF-selective pharmacophores, they created two BOLT ligands: AZ13-tet containing the AZ628 pharmacophore and AZ181-tet containing the PLX4720 pharmacophore, which are significantly distinguished from the previous iBOLT ligands 279 with photoisomerizable linkers
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Moreover, a ketogenic diet, characterized by lower carbohydrate intake and relatively increased consumption of fats and proteins, holds potential in rectifying metabolic and inflammatory imbalances related to psoriasis (102)
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