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Phenotype enrichment analysis also revealed that genes downregulated by NAC are involved in oxidative and toxic metal stress resistance, suggesting that SKN-1, an ortholog of the mammalian master regulator of oxidative stress defense, NRF-2, is negatively regulated by NAC (Supplementary Fig
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In addition, obesity/hyperlipidemic factors like serum cholesterol and triglycerides were also reduced in animal models upon treatment with lectins (Sawant et al., 2017)
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