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Reduced and oxidized glutathione in the substantial nigra of patients with Parkinson’s disease

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Ibudilast Ibudilast is known to target multiple pathways, and the RNAseq results demonstrated that ibudilast treatment reduced inflammation by lowering the expression of several pro-inflammatory proteins, including cytokine interleukin (IL)-6, interferon receptor 1, macrophage migration inhibitory factor, microglial proteins such as transmembrane protein 119, arachidonate 5-lipoxygenase activating protein, toll-like receptor 7, lysosomal protein transmembrane 5, and triggering receptor expressed on myeloid cells 2