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Subjects administering AOD9604 experienced sustained lipolysis without any of the negative side effects typically associated with systemic growth hormone use, such as impaired glucose tolerance, insulin resistance, or IGF-1 mediated tissue growth
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Published mouse studies using oral and IP administration of NNMT inhibitors demonstrate significant reductions in body weight, fat mass, and plasma lipids in diet-induced obesity models, establishing oral bioavailability as a feature of this compound class
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