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The “metabolism” is the most abundant category, and the DEGs were mainly enriched in “glycolysis/gluconeogenesis,” “oxidative phosphorylation,” “purine metabolism,” “starch and sucrose metabolism,” and “glycerophospholipid metabolism.” From the gene number and rich factor, the DEGs were mainly enriched in “ribosome,” “spliceosome,” “yeast cell cycle,” “glycolysis/gluconeogenesis,” and “oxidative phosphorylation” pathways (Figure 4B)

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Adenine, isovalerylglutamic acid, uric acid ribonucleoside, 1,5-anhydroglucitol, dehydroepiandrosterone, sialyllactose, Nϵ-acetyl-L-lysine, and nonanoylcarnitine were the top urine metabolites that predict PE with high accuracy