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Evaluation of fat mass and lean mass using Echo-MRI and X-ray CT system Body components of fat and lean mass were measured using the Echo-MRI system according to the manufacturer’s instructions (Hitachi Aloka Medical Ltd., Tokyo, Japan) at 1 day before dosing and 14 days after dosing without anesthesia

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These were L-NAME responsive/L-arginine responsive, L-NAME responsive/L-arginine non-responsive, L-NAME non-responsive/L-arginine responsive, opposite or parallel, NO-specific (L-NAME and L-arginine counteract each other’s response), or NO-non-specific (L-NAME and L-arginine do not counteract each other’s response) (Table 3)