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Metabolite 22 is formed by nucleophilic addition of water to the reactive amitriptyline-epoxide intermediate 21 , which is generated by P450-catalyzed bioactivation of an aromatic ring of amitriptyline (Fig
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The carnitine system and its implication in cancer cells metabolic plasticity The use of diet-derived or adipose tissue-released long-chain fatty acids as energy substrates requires about 25 different enzymes and transport proteins, which carry out fatty acids, import, them into mitochondria, and facilitate the β-oxidation steps
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