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Adiponectin expression and levels in circulation are upregulated by rosiglitazone.[22] TREATMENT OF ACANTHOSIS NIGRICANS Therapeutic approach involves treatment of underlying disease or tumor, cessation/avoidance of the inciting agent in drug-induced AN, use of topical/oral agents and cosmetic surgery.[12] Weight loss and exercise have shown to increase insulin sensitivity and reduce insulin levels causing improvement in obesity associated AN.[23] Correction of hyperinsulinemia reduces hyperkeratotic lesions

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Age matters: An atypical association between polymorphism of MTHFR and clinical phenotypes in children with schizophrenia