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On the other hand, disruption of ZC3H7A , MCM8 or MCM9 were identified to drive GSC sensitivity to TMZ following a negative selection CRISPR KO screen in response to sublethal doses of TMZ [64]
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This upregulation remodels fatty acid metabolism ( 4 Innate immune and DKD 4.1 Intrinsic immune cells Innate immune cells are present in blood and tissues and can be categorized into classical innate immune cells stemming from common myeloid precursors in the bone marrow ( Figure 2 ), including monocytes, macrophages, mast cells, and neutrophils
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