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Mutations N8.47(384)A and L6.37(325)A have been shown to reduce Gq coupling, whereas RICL2(185)A and N2.37(107)A negatively impact the efficacy of agonists, suggesting that these may play a primary role in signaling as well (Kim et al, 2020)
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[DOI] [PubMed] [Google Scholar] 151.Stoytcheva ZR, Berry MJ
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