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The accumulation of misfolded proteins, will exert mitochondrial stress (Dell’Anna et al., 2001), in which nucleus receives a signal and ultimately activates UPR (Harris, 2016), that help reestablish the ER homeostasis by increasing the protein folding capacity of the ER, and decrease the ER protein folding loads
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Roles of natural killer cells in immunity to cancer, and applications to immunotherapy
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