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The study has also determined that rs2476601 within PTPN22 was the best predictor for insulin AAb appearing first and that rs231775 at CTLA4 is correlated with GAD AAb at initial seroconversion (243)
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Upon binding, the peptide initiates a Gs-protein coupled intracellular signalling cascade that amplifies cyclic adenosine monophosphate (cAMP) concentrations
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