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The factor responsible turned out to be a small copper-binding tripeptide whose endogenous concentration declines with age — from roughly 200 ng/mL at age 20 to 80 ng/mL at age 60. The 50-year research arc that followed makes GHK-Cu one of the most thoroughly characterized small peptides in the literature
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Thus 5-oxoproline in cells often accumulates and some of it is found to be secreted into the plasma (Van Der Werf et al., 1974)
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