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Collectively, these findings position HFD as a potent driver of gut-brain communication toward a proinflammatory state associated with cognitive impairment and neurodegenerative disease risk ( Similarly, negative repercussions have been reported as a result of elevated levels of trimethylamine N-oxide (TMAO), a product of microbiota-dependent metabolic breakdown of dairy, egg, fish and meat (Zhu et al., 2021), reinforcing the link between dietary substrates, microbial metabolism, and cerebrovascular risk

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