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This is one reason BPC-157's gut-protective mechanisms are considered potentially relevant to PMOS, though human clinical evidence remains limited
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Specifically, miR-9 and miR-34a have been found to be up-regulated in aging and both target Sirt1 mRNA, which is found to be down-regulated contributing to enhanced gene expression ( Modulation of ncRNAs has also been observed in aging, and the ncRNAome is tissue-specific
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