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This promotes NADPH oxidase-derived ROS, which activates the TGF-β/Smad3 signaling pathway, ultimately leading to renal interstitial fibrosis (Wang H
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plantarum Lp91 attenuated colonic inflammation in murine models by decreasing TNF-α, Cyclooxygenase-2 (COX-2), and Interleukin-4 (IL-4) expression [146]
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