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In breast cancer research, network tools such as Cytoscape (292), STRING (293), and Weighted Gene Co-expression Network Analysis (WGCNA) (294) have characterized several functional modules, such as the PD-L1/PD-1 axis, cyclin-dependent kinases (CDKs), BRCA1/2 complexes, and more, by analyzing transcriptomics and proteomics together
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Three derivatives of the D-Nle-X-Ile-(6)amino- hexanoic amide, where X is: Cys, Trp, or Met were examined to determine whether the percent of inhibition of dimerization and the binding affinity for each compound for HGF could be correlated to in vitro cellular activity, namely inhibition of MDCK cell scattering
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