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Elevated resistin levels activate the c-Jun N-terminal kinase (JNK) pathway, which phosphorylates IRS-1 at serine residues, impairing its function and resulting in reduced glucose uptake and heightened insulin resistance ( In a recent investigation involving insulin-resistant rats subjected to a high-fat diet (Wang X
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Cotter, L., Rae, M., McGough, M., Panchal, N., Wager, E., Cox, C., & Claxton, G
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