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However, the signaling through TNFR1(p55) is complex and can also trigger a nuclear translocation of NF-kappa B and transcription of its target genes including both anti-apoptotic factors (e.g., IAPs, Bcl-2, Bcl-xL) and pro-inflammatory factors (e.g., cytokines, chemokines) (Figiel, 2008)
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