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Targeted therapeutics The dynamic interplay between lactate metabolism and lactylation-driven epigenetic reprogramming has emerged as a hallmark of diverse pathological processes, such as cancer, inflammatory disorders, and metabolic syndromes
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GCL is considered the speed limiting enzyme of synthesis since overexpression of GS does not increase GSH levels while overexpression of GCL increases the synthesis of GSH (61) (Figure 3)
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