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For example, AMPK activation can prevent the synthesis of fatty acids and cholesterol by upregulating the expression of genes involved in fatty acid oxidation and lipid decomposition, such as peroxisome proliferator-activated receptor γ coactivator 1 ( Pgc1 ) and adipose triglyceride lipase ( Atgl ), and by down-regulating the expression of adipogenesis genes such as FAS and ACC [181]
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Overall, pharmacological modulation of cardiac metabolism is clinically feasible, with SGLT2 inhibitors leading the field and other agents showing promise pending further validation (Table 1)
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