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Purslane Ameliorates Inflammation and Oxidative Stress in Diabetes Mellitus: A Systematic Review
4.4.4 Targeting the Nrf2–GPX4 signaling pathway to inhibit ferroptosis in PD Nuclear factor erythroid 2-related factor 2 (Nrf2) functions as a master regulator of cellular antioxidant defenses and plays a direct role in modulating GSH biosynthesis, enhancing oxidative stress resistance, and suppressing ferroptosis (275, 276)
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For kinetoplastid diseases, this requires reconsidering pharmaceutical interventions to include veterinary therapeutics, environmental stewardship, and collective surveillance systems—a holistic approach to observe, monitor and treat the disease in its zoonotic totality
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