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Glutathione synthetase deficiency: is gamma-glutamylcysteine accumulation a way to cope with oxidative stress in cells with insufficient levels of glutathione

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It is well established that the ovarian factor—the decline in oocyte quantity and quality, which occurs because of an increase in meiotic errors in this finite pool—becomes a more important consideration with age (Horan and Williams, 2017) when oocyte stem cells were isolated from mouse ovaries (Johnson et al., 2004), most current evidence points to the existence in human ovaries of a more or less finite, non-renewable, pool of oocytes which is gradually depleted until menopause