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Oxidative stress-induced damage in chronic intestinal disorders is associated with mucosal infiltration by activated leukocytes, which produce excessive ROS that overwhelm the tissue’s antioxidant defenses and perpetuate or exacerbate mucosal inflammation
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Liver tropism remains the benchmark for clinically validated nucleic-acid delivery: the first FDA-approved siRNA agent, Onpattro, corroborates liposomes as the most mature platform for hepatocyte targeting [220]
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