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Methylation changes in relationship to disease activity: transcription factors highlighted There are only a few studies examining DNA methylation changes associated with disease activity defined by the SLE Disease Activity Index (SLEDAI) score
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The glycolytic product lactate may regulate the activity of HIF-1Ξ± to block the release of mitochondrial ROS mediated by PDH, thereby regulating the necroptosis induced by RIPK (Chen et al., 2023
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