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Additionally, environmental stressors like heavy metals and pesticides have been shown in experimental models to impair proteasome function, promote ฮฑโsyn aggregation, and drive dopaminergic neuron loss, underscoring the multifaceted contribution of UPS impairment to PD pathogenesis [170]
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โข Group (IV) PCOS rats were induced by EV (60 days) and then treated with genistein for 14 days (genistein-treated PCOS group)
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