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Similarly, pre-treatment of mice with ethanolic extract of leaf (25, 50, and 100 mg/kg) reduced systemic production of pro-inflammatory factors, such as interleukin-5 ( ⋅ production was decreased at doses of 5 or 50 mg/kg administered 6-h previous to inflammation induction (Maciel et al., 2008)

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Simultaneously, nonparenchymal cells, such as KCs, HSCs, and newly recruited immune cells, are activated and produce pro-fibrotic and pro-inflammatory mediators [72]