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169 Deficiency of Cu has been shown to suppress transcriptional activity of NF-κB, thus inhibiting the expression of pro-angiogenic factors such as bFGF, vascular endothelial growth factor (VEGF), IL-8, IL-6, and IL-1α
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His lab has focused on understanding an inherited genetic condition called alpha-1 antitrypsin deficiency (ATD), in which accumulation of a misfolded protein causes severe liver damage in some of the affected individuals
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