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P=0.005) • ASCT appeared to have a consolidative rather than independent effect in time-dependent analyses • Increased use of intensive regimens and ASCT post-2016, with similar survival outcomes across eras • scRNA-seq identified transcriptional features suggestive of altered immune differentiation and myeloid-associated immunoregulatory signaling Why this study matters The study analyzed 127 patients with newly diagnosed pPCL from 20 Korean centers and identified factors associated with 6-month early mortality and survival, including performance status, lactate dehydrogenase, del(17p), and complete remission
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