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Potential antagonistic effects Conversely, curcumin has been shown to interfere with the action of other chemotherapeutic drugs (e.g., cyclophosphamide, doxorubicin) by activating certain detoxification pathways (like ABC transporters) that pump the drugs out of cancer cells, thereby reducing their effectiveness (244)
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These could be further validated in in vivo models, such as the LTL331 model, that transdifferentiate from adenocarcinoma to NEPC after castration [100]
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