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Pathogen-Associated Molecular and Damage-Associated Molecular Patterns Inflammatory conditions are triggered by two mechanisms: either exposure to exogenous ligands from pathogenic microbes during an infection, known as PAMPs, or exposure to intracellular or extracellular stress-induced molecules or tissue damage components, known as DAMPs [115,128,129]
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Phase I proposers should suggest an appropriate sandbox or simulation plan for future evaluation, showing how their architecture supports realism, adversary engagement, and dynamic behavior without needing a fixed environment
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