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In reality, post-translational modifications, bound ligands, cofactors, and the three-dimensional protein structure can shift the empirical pI by 0.5 to 1.5 pH units
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Isothiocyanates likely inhibit the expression and function of hypoxia inducible factors (HIFs) that control angiogenesis, as reported in endothelial cells and malignant cell lines (35)
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