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At low physiological levels (nanomolar concentrations), species involved in redox signaling (e.g., H 2 O 2 ) are crucial in metabolic regulation and adaptation to any changes in the cellular environment, possibly by being involved in various post-translational modifications, -a state of oxidative eustress

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Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)

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