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Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice
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One central pathway is the PI3K/Akt cascade, which is a well-known regulator of cell metabolism, proliferation and survival (108), and can be directly stimulated by FSHR following direct interaction with 14-3-3τ adaptor proteins (109)
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