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HCC, widely regarded as a metabolic disorder, exhibits particularly prominent dependencies and adaptations in its TCA cycle, providing a strong rationale for novel therapeutic targeting [46,48]
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( CYP27B1 ), which converts 25(OH)VD to its active metabolite [1alpha,25-dihydroxyvitamin D3, 1,25(OH) 2 VD], is present in both renal (major site) and nonrenal tissues (1)
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