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As summarized above, a wide range of putative inhibitors of the HGF/c-MET axis is currently available and under investigation, such as tyrosine-kinase inhibitors, last-generation antibodies, or even miRNA mimics [Figure 2]
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Tbx1 is only expressed in a subset of brain vessels (∼1.5% of brain cells) in the adult mouse (24), but it excludes significant non–cell-autonomous transcriptional effects on the brain parenchyma
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