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doi: 10.1093/cercor/bhab107

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Timing and Frequency Dose once daily due to MK-677’s long half-life (~24 hours) Can be taken in the morning to avoid excessive hunger before bed, or at night to enhance sleep and GH output during deep sleep Avoid taking it immediately before heavy carbohydrate meals, as insulin blunts GH response Cycle Duration Standard cycle: 8–12 weeks Extended use: Up to 6 months in therapeutic settings Because MK-677 doesn’t suppress natural GH production, long-term use is possible, but users should monitor glucose, insulin sensitivity, and appetite over time Reversible Effects All of MK-677’s actions are reversible—meaning: Appetite returns to baseline after discontinuation IGF-1 levels normalize within 7–10 days Water retention clears after cessation No post-cycle therapy (PCT) is needed, as it doesn’t suppress testosterone or natural GH release MK-677 is a low-barrier entry into GH optimization, but proper dosing helps avoid overuse