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Common CNS causes include: Stroke or TIA — sudden interruption of blood flow to the brain, producing one-sided weakness or numbness, facial drooping, or speech difficulty Multiple sclerosis — demyelination in the brain and spinal cord causing episodic or progressive numbness, weakness, and balance problems Spinal cord compression — from injury, tumor, or severe disc disease, producing weakness and numbness below the level of compression Brain tumors — depending on location, can cause focal weakness, sensory changes, or coordination problems Distinguishing peripheral from central causes guides the urgency and type of workup needed