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The first is Inotuzumab Ozogamicin (CMC-544), an IgG4 kappa monoclonal Ab with N -acetyl-γ-calicheamicin dimethyl hydrazide, a semi-synthetic derivative of calicheamicin linked by 4′-acetylphenoxy-butanoic acid [140], which was FDA-approved in August 2017 for R/R B cell ALL
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