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Treatment with gossypol, an inhibitor of ALDH, reduced oxphos in the resistant lines in vitro while the combination of gossypol, irinotecan, and phenformin (Complex I inhibitor) synergistically reduced tumor size in therapy naive cells in vivo (Lee et al., 2020)
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It’s very plausible that a doctor’s concern regarding potential B12 toxicity may arise from the fact that elevated levels of B12 often indicate a serious underlying condition
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