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Topical depigmenting agents, such as hydroquinone, azelaic acid, kojic acid, licorice extract, and retinoids, can be effective alone or in combination with other agents, and procedures such as chemexfoliation and laser therapy can also be incorporated into the management strategy if needed (Table 2)

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After 18 weeks, the authors discovered that the antioxidants in the fruit “turned on” antioxidant defense pathways, which ultimately increased the activity of genes that boost the production of glutathione