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Besides, both depressive and manic subgroups were characterized by presenting low levels of KYNA in comparison to healthy controls, which seems to support the relevance of the Kyn pathway in the context of neuroinflammation in BD and how it may be differentially modulated
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Key regulators such as SLC7A11, GPX4, ACSL4, FSP1, and TP53 critically influence this process, with their modulation helping to overcome radioresistance
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