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9.1 Integrated discussion on mechanistic evidence strength, gaps, and confounding factors (1) Strength ranking of core mechanistic evidence and prioritization for clinical translation Based on a systematic analysis of each nutrient's regulatory pathway, the mechanisms with the strongest evidence for clinical translation are prioritized as follows: Omega-3 polyunsaturated fatty acids (EPA/DHA) → anti-inflammatory pathway: Supported by human RCTs ( Dietary fiber → gut microbiota → SCFA pathway: Validated by human intervention studies (124), such as trials showing THAT inulin supplementation increases fecal butyrate levels and reduces scores on the BDI-II
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