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5A, all the combination including triple-components (ZCQ) and dual-components (ZC, ZQ, CQ) showed significant inhibitory effect on inflammation as the expression of TNF-α and IL-6 in ZCQ group was significantly lower than the single component treatment with Zn 2+ , Cu 2+ or Qu alone, which suggests the unique synergistic effect of Zn 2+ , Cu 2+ and Qu
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